Effective treatment of insomnia with mirtazapine attenuates concomitant suicidal ideation. Sleep Med. Acute effects of mirtazapine on sleep continuity and sleep architecture in depressed patients: a pilot study.
Jul 1;48 1 Leonard, S. UCLA Health, 1— 2. Kolla, B. The influence of antidepressants on restless legs syndrome and periodic limb movements: A systematic review. Sleep med. Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men. JCI Insight. Jan 10;4 1. Ruigt, G. Effect of the antidepressant Org on human sleep. For people with liver problems: If you have liver problems or a history of liver disease, you may not be able to process this drug as well.
For pregnant women: Mirtazapine is a category C pregnancy drug. That means two things:. This drug should only be used if the potential benefit justifies the potential risk.
For women who are breastfeeding: Mirtazapine may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. For seniors: The kidneys of older adults may not work as well as they used to.
This can cause your body to process drugs more slowly. As a result, higher amounts of a drug stay in your body for a longer time. This raises your risk of side effects, such as confusion or drowsiness. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:. The kidneys of older adults may not work as well as they used to. This raises your risk of side effects.
Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you. Mirtazapine is used for long-term treatment. If you suddenly stop taking mirtazapine, you may have withdrawal symptoms.
These can include:. For this drug to work well, a certain amount needs to be in your body at all times. If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:. If your symptoms are severe, call or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects. How to tell if the drug is working: You should have decreased symptoms of depression and be in a better mood. Note that it may take 4 weeks before this drug works to treat your depression. Discuss this with your health care provider.
Do not double your next dose or take more than what is prescribed. Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications. They may decrease the benefits e. If an overdose occurs, call your doctor or You may need urgent medical care. You may also contact the poison control center at Angle closure glaucoma symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye Agranulocytosis low white blood cell count can increase the risk of infection.
If you develop symptoms of infection, such as fever, chills, sore throat, swelling of the lining the mouth or other possible signs of infection, contact your prescriber.
Serotonin syndrome symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death , seizures. To date, there are no known problems associated with long term use of mirtazapine. It is a safe and effective medication when used as directed.
Mirtazapine should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors MAOIs. Sleep, energy, or appetite may show some improvement within the first weeks.
Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to weeks to fully improve.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults age 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If you start to have problems with your weight while taking mirtazapine, talk to your doctor or pharmacist. You can drink alcohol while taking mirtazapine but it may make you feel sleepy and unsteady on your feet. It might be best to stop drinking alcohol for the first few days of treatment until you see how the medicine affects you. Drinking alcohol every day or in large amounts can make your symptoms worse.
It also makes it harder for mirtazapine to work properly. Try to stick to the national guidelines of no more than 14 units a week.
A standard glass of wine ml is 2 units. A pint of lager or beer is usually 2 to 3 units of alcohol. Mirtazapine will not affect any type of contraception, including the combined pill or emergency contraception. There's no firm evidence to suggest that taking mirtazapine affects male or female fertility. Speak to your doctor if you're planning to get pregnant or become pregnant while taking mirtazapine. Some people can't concentrate properly while they are taking mirtazapine.
When you first start taking mirtazapine, it's a good idea to stop driving and cycling for the first few days until you know how this medicine makes you feel. Cannibis with mirtazapine can make you feel very sleepy, especially if you've just started taking mirtazapine. Mirtazapine hasn't been properly tested with recreational drugs. Talk to your doctor if you think you might use recreational drugs while taking mirtazapine. Page last reviewed: 1 February Next review due: 1 February Mirtazapine On this page About mirtazapine Key facts Who can and can't take mirtazapine How and when to take it Side effects How to cope with side effects Pregnancy and breastfeeding Cautions with other medicines Common questions.
About mirtazapine Mirtazapine is an antidepressant medicine. Help us improve our website Can you answer a quick question about your visit today? Mirtazapine usually takes about 4 to 6 weeks to work. Common side effects include headaches, dry mouth and feeling sick. They're usually mild and go away after a couple of weeks.
If you and your doctor decide to take you off mirtazapine, your doctor will probably recommend reducing your dose gradually to help prevent extra side effects. Mirtazapine is not a sleeping tablet but it can make you feel sleepy. This can be helpful if you have depression and difficulties getting to sleep. Mirtazapine is also known by the brand name Zispin SolTab. Check with your doctor before starting to take mirtazapine if you: have had an allergic reaction to mirtazapine or any other medicines in the past have a heart problem as mirtazapine can cause low blood pressure have ever taken any other medicines for depression — some rarely used antidepressants can interfere with mirtazapine to cause very high blood pressure even if you've stopped taking them for a few weeks have an eye problem called glaucoma — mirtazapine can increase the pressure in your eye have epilepsy — although it's rare, mirtazapine may increase your risk of having a seizure are trying to become pregnant, already pregnant or breastfeeding are taking warfarin - mirtazapine may increase the effects of warfarin and blood clotting If you have diabetes , mirtazapine can make it more difficult to keep your blood sugar stable.
Mirtazapine can be taken with or without food. How much will I take? What if I forget to take it? If you take mirtazapine twice a day and forget: your morning dose — take it together with your evening dose your evening dose — do not take it with the next morning dose. Instead skip the missed dose, and then continue the next day with your normal morning and evening doses both doses — skip the missed doses. Do not take an extra dose to make up for a missed dose If you forget doses often, it may help to set an alarm to remind you.
What if I take too much? Urgent advice: Call your doctor straight away if you take too much mirtazapine. Common side effects These side effects happen in more than 1 in people.
Call your doctor straight away if you experience: severe pain in your stomach or back, and nausea — these can be signs of inflammation of the pancreas pancreatitis thoughts about harming yourself or ending your life constant headaches, long-lasting confusion or weakness, or frequent muscle cramps — these can be signs of low sodium levels in your blood which can cause seizures in severe cases yellow skin, or the whites of your eyes go yellow — this can be a sign of liver problems high fever, sore throat and mouth ulcers — these signs of infection could be due to a problem with your blood cells Serious allergic reaction In rare cases, it's possible to have a serious allergic anaphylaxis reaction to mirtazapine.
Information: You can report any suspected side effect to the UK safety scheme.
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