For a supplement, little scientific support. DMSO , or dimethyl sulfoxide, has a long history as a topical anti-inflammatory agent. Certain precautions must be taken when applying DMSO, and it should only be used under the guidance of a qualified healthcare professional. The use of dimethyl sulfoxide DMSO for therapeutic applications is controversial in part because some claims made by advocates appear to extend beyond current scientific evidence, and in part because topical use greatly increases the absorption of any substance that happens to be on the skin, including molecules that are toxic to the body.
Nonetheless, there is some preliminary evidence that when applied to the skin, it has anti-inflammatory properties and alleviates pain, such as that associated with RA. DMSO appears to reduce pain by inhibiting the transmission of pain messages by nerves. It comes in different strengths and degrees of purity, and certain precautions must be taken when applying DMSO.
For these reasons, DMSO should be used only under the supervision of a doctor. DMSO applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the abnormal connective tissue associated with disorders such as Dupuytren's contracture, keloids, Peyronie's disease, and scleroderma. Research on the use of topical DMSO to treat Dupuytren's contracture remains preliminary and unproven. Oral supplementation with dimethyl sulfoxide DMSO reduced relapse rates for peptic ulcer significantly better than did placebo or the ulcer drug cimetidine Tagamet in one study.
Previous research showed that DMSO in combination with cimetidine was more effective than cimetidine alone. These trials used mg of DMSO taken four times per day. The authors of these trials believe the antioxidant activity of DMSO may have a protective effect. Oral supplementation with DMSO should not be attempted without the supervision of a doctor. The use of DMSO , a colorless, oily liquid primarily used as an industrial solvent, for therapeutic applications is controversial.
However, some evidence indicates that dilutions, when applied directly to the skin, have anti-inflammatory properties and inhibit the transmission of pain messages by nerves, and in this way might ease the pain of minor injuries such as sprains and strains. However no controlled research exists to confirm these effects in sprains and strains.
DMSO comes in different strengths and different degrees of purity. In addition, certain precautions must be taken when applying DMSO. For those reasons, DMSO should be used only with the supervision of a doctor. DMSO is not indicated for healthy people. Those who do use this substance should consult a doctor familiar with its use. Some physicians do not recommend the use of DMSO due to concerns about safety and questions about efficacy.
The potential for contamination exists in some DMSO products designed for industrial uses. DMSO used topically is rapidly absorbed through intact skin. DMSO is derived from trees as a manufacturing by-product from the processing of paper. Metabolites breakdown products of DMSO, such as the sulfide and sulfone forms, are naturally present in the human body. However, the role of these in the body is not clear. DMSO is not an essential nutrient and it is not needed in the functions of a healthy body; therefore, deficiencies do not exist.
DMSO frequently causes a garlic -like body odor and taste in the mouth. Other reported side effects include stomach upset , sensitivity to light , visual disturbances, and headache. Skin irritation can develop at the site where DMSO is applied topically. Only highly purified, properly diluted DMSO should be used and the skin site and applying hand should be thoroughly cleaned before application, because the solvent properties of DMSO allow contaminants to be absorbed through the skin and transported into the bloodstream.
Improperly diluted DMSO can also burn the skin. Check with a healthcare professional for appropriate use. Learn more about TraceGains, the company. The information presented by TraceGains is for informational purposes only. It is based on scientific studies human, animal, or in vitro , clinical experience, or traditional usage as cited in each article.
This property makes the compound especially versatile. DMSO can also reduce swelling in the brain and spinal cord, which can be literally lifesaving in diseases like West Nile encephalitis. DMSO may be used to draw fluids out of the lungs in cases of acute pulmonary edema. Because it pulls water from tissues, DMSO has a diuretic effect, meaning it makes a horse urinate more. This can help flush toxins from the body more quickly. With this action in mind, DMSO is often given intravenously in the treatment of cantharidin poisoning blister beetle toxicity , to lessen the effect of the toxin on the kidneys and intestinal tract.
After episodes of tying up, DMSO may help horses eliminate waste products of muscle breakdown through their urine more quickly. The diuretic action of DMSO, however, can make it unsafe for horses who are dehydrated or in shock. It can further dehydrate these animals or dangerously lower their blood pressure. For instance, treating rainrot or other skin infections can be difficult because the responsible organisms are buried deep under the skin or crusty, painful scabs.
However, a mixture combining antibacterial medication with DMSO can pass through the skin and reach the affected area. For the same reason, DMSO is often added to antifungal medications for treatment of eye conditions and sometimes to steroids for targeted, topical anti-inflammatory treatment.
Likewise, avoid mixing DMSO with substances that could be toxic if ingested, such as organophosphates or mercury salt.
Research shows that DMSO slows or blocks conduction of impulses along nerve cells, which in effect reduces pain from musculoskeletal injuries, postoperative incisions and other sources.
Relief is only temporary—lasting up to a few hours—because as the DMSO dissipates, normal nerve function returns. It can be combined with other pain-relieving drugs, however, to extend the analgesic action. Some applications of DMSO combine all of these: For instance, it is often used in surgical colic cases to reduce the risk of tissue adhesions due to inflammation and poor circulation; some surgeons think that it may also provide some pain relief in the hours following surgery.
The Jockey Club allows 10 micrograms per milliliter of plasma. If you compete with your horse, check any governing association rules regarding DMSO use. Also keep in mind that because DMSO can move other materials through the skin, combining it with other medications could result in a violation of thresholds for both.
A search of a research database will turn up a good sampling of peer-reviewed papers on DMSO use in horses, but the compound has gotten far less scientific scrutiny than have medications developed specifically for therapeutic applications. Scant information is available regarding dosing.
Often veterinarians rely on their own experiences and those of their colleagues in deciding when and how to use DMSO. Whether applied topically, orally, intravenously or by injection, DMSO requires careful handling. If you do, keep these basic facts in mind to make sure your horse benefits fully from this unusual preparation. Don't miss out! With the free weekly EQUUS newsletter, you'll get the latest horse health information delivered right to your in basket!
Behavioral Problems. Medications and Drugs. Horse Care. Farm and Ranch. Hoof Care. Injuries and First Aid. Parasite Control. Preventative Care. Senior Horse Care. Tack and Apparel. Horse World.
Barn Dogs. Ride along with a veterinarian. Basic training with David O'Connor. Beyond the Saddle Podcast. The Jurga Report.
0コメント